Applications

best_buchi_62_NIR-spectroscopy_EN_1105.pdf

The identity of clinical test samples has to be verified regularly (placebo – verum). This task requires not only a fast but above all a nondestructive method. Without doubt FT-NIR transmission spectrocopy is the preferred technology for the analysis of intact tablets and BÜCHI Labortechnik AG has been identified as a competent provider and partner. The NIR experiments led not only to a validated method that could differentiate between the active ingredient and the placebo, but also yielded the prospect of the ability to discriminate between the individual strengths. An emerging task was the need to transfer the calibration from an earlier BUCHI instrument (NIRTab) to the current NIRFlex N-500 model.

best_buchi_61_Determination_in_milk_by_Kjeldahl_en.pdf

There are only few foodstuffs that are as closely connected to the history of mankind as milk. Not only does milk taste good, it is also a healthy and nutritious food, in fact one of the most valuable foodstuffs there is; it contains ealthy protein for building up muscles, calcium for strong bones and teeth, milk sugar for good digestion and vitamins for a strong immune system. Milk protein is very valuable because it contains a large proportion of essential amino acids and is therefore indispensable for the structure of body cells (such as muscles, organs, skin, hormones, enzymes).

best_buchi_60__Spray_Drying_Acid_resistant_B-290_low.pdf

The acid resistant Mini Spray Dryer B-290 version is made to spray dry acid solutions in open mode configuration. It comprises a highly effective perfluoroalkoxy polymer coating (PFA) on the metallic parts of the spray dryer which are in contact with the product and drying gas. The coating prevents corrosion and results a good quality similar to polytetrafluoroethylene (PTFE).

Best_Buchi_59_Laboratory_Scale_Spray_Drying_of_inhalable_drugs.pdf

The Mini Spray Dryer B-290 from Büchi Labortechnik AG is a laboratory scale instrument to perform spray drying processes down to 30 mL batch volume and up to 1 litre of water or organic solvent per hour. Thanks to the glassware, the complete drying process from the two-fluid nozzle down to the powder collection vessel is visible. Fine particles are produced because of the short residence time in such a compact spray dryer. The residence time of the drying air within the spray chamber is about 1.5 seconds. The powder collection is provided by a glass-made cyclone separator, which is internally coated with a thin nanosize antistatic film to reduce powder adhesion to the glass wall. The separation works by centrifugal forces by virtue of iner tia of the solid particles.

Best_Buchi_58_Nitrogen_Determination_with_Kjeldahl.pdf

Kjeldahl is one of the most commonly used techniques to determine the protein content in food and feed samples. The detection and quantification limits are important characteristics of analytical methods. The impact of the concentration of boric acid, the addition of potassium chloride, and the concentration of the titration solution on the detection and quantification limits were investigated. The best results were obtained by using 2 % boric acid with 3 g potassium chloride per liter. A titration solution of 0.005 M HCl worked best. With these parameters, detection limits for distillation of standard solutions as low as 0.008 mg nitrogen and quantification limits of 0.02 mg nitrogen can be achieved.

Best_Buchi_57_Laboratory_Scale_Spray_Drying_of_Lactose.pdf

Spray drying is a commonly practiced method to prepare inhalable powders. This study reviews recently published scientific work in the field of lactose spray drying for inhalable applications using Buchi laboratory scale spray dryers.

best_buchi_56_Calibration_transfer_NIR_Checkmaster_RGB.pdf

According to Process Analytical Technology (PAT) it is important to check certain parameters during tablet production. These parameters include the tablet weight, the diameter, the thickness and the hardness. For this purpose the Checkmaster of the Kraemer GmbH ELEKTRONIK can be integrated into the production process.

Best_Buchi_55_Determination_of_PBDEs.pdf

The efficiency of pressurized solvent extraction (PSE) was investigated by comparing PSE with automated Soxhlet extraction. Sediment samples containing polybrominated diphenylethers (PBDEs) were processed in the Speed Extractor E-914 for PSE and in the Extraction System B-811 for automated Soxhlet extraction. Quantification of PBDEs was performed by GC-MS. This study shows that both techniques are comparable in terms of accuracy recovery and reproducibility and confirms that PSE is a much faster technique consuming much less solvent than automated Soxhlet extraction.

Best_Buchi_Nr.54_Syncore.pdf

Syncore® Analyst allows for efficient and parallel concentration of liquid samples in less than one hour and minimizes the environmental impact by solvent recovery. These advantages make the Syncore® Analyst the system of choice for concentration in trace analysis. A best practice guideline is presented below.

Calibration_with_NIR_Spectroscopy.pdf

In order to create a precise and robust calibration model for determining the active ingredient content of tablets, it is essential to choose a suitable calibration range. This range should cover at least 75 -125% of the nominal content of the active ingredient in 5% steps, in order to achieve sufficient accuracy of the calibration model. In the following the creation of two calibration models is described.

Best_Buchi_52_Scale-up_B-290_Niro_MOBILE_MINOR.pdf

This Best@Buchi describes a hands-on approach to perform a scale-up from initial trials in the research lab with the Mini Spray Dryer B-290 to laboratory production with the Niro MOBILE MINOR spray dryer. Guidelines to adjust the droplet size of the spray and the relationships between water evaporation rate, inlet and outlet temperature are explained. Contact Büchi's and Niro's experts at the customer test centres for feasibility testing of your product!

Best_Buchi_51_PAH.pdf

The Extraction System B-811 and the Syncore Analyst parallel concentrator from Buchi as well as the Pressurized Solvent Extractor from Applied Separations were evaluated for the pretreatment of samples containing PAHs. Recoveries of extraction and subsequent concentration using acetone+n-hexane (1+1) were 70-95% for 2 ring and 90-100% for the less volatile 3-5 ring PAHs. A good precision (95% confidence level) of less than 6%, naphtalene excluded (12%), was found. No significant difference was observed between the two extraction methods.